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This long-form article will dissect every possible reason why the Multikey fails, from Windows security updates to driver signature enforcement, and provide step-by-step solutions.
If the drivers seem fine but Mastercam still won't open, use the built-in licensing utility.
It is important to note that "Virtual USB Multikeys" are rarely used by legitimate, licensed software holders. Mastercam typically uses a physical USB "Sim" (Security Identification Module) or a cloud-based license server.
For permanent disable (not recommended for security):
(Windows cannot verify the digital signature) in the Device Manager. Device Status: The "Virtual USB MultiKey" entry often appears with a yellow exclamation mark under "Universal Serial Bus Controllers".