Tools like the integrate directly with the build system. Instead of hex codes, you can edit a color.c file directly:

def sm64_color(r, g, b): # Convert 0-255 to 0-31 r5 = round(r / 8) g5 = round(g / 8) b5 = round(b / 8) # Combine into 16-bit value return (r5 << 10) | (g5 << 5) | b5